As cem drogas mais rentáveis, equivalem à metade
do PIB da África do Sul (32º maior PIB mundial)!
172 bilhões de dólares!
Qual a droga mais prescrita nos Estados Unidos no último ano? Levotiroxina.
A segunda mais? Crestor (rosuvastatina) = custo de 5,7 bilhões de dólares
A terceira mais? Nexium (esomeprazol) = custo de 6,3 bilhões de dólares
O custo total das 100 drogas mais rentáveis, SOMENTE nos Estados Unidos, somam astronômicos US$ 172.410.523.282. São 172,4 bilhões de dólares. Para se ter uma comparação, o PIB da Argentina (29º maior PIB Mundial - http://economia.terra.com.br/pib-mundial/) tem previsão de 404 bilhões para 2014. É a metade do PIB da África do Sul (32º maior PIB) que é de 350 bilhões.
Quanto essa indústria não influencia nosso dia-a-dia e nossas referências (trials, guidelines etc.)?
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| Fonte: http://outraspalavras.net/ |
Top 100 Most Prescribed, Top-Selling Drugs
There has been little change in top-prescribed and top-selling prescription drugs in the United States, according to the latest data from research firm IMS Health.
Hypothyroid medication levothyroxine (Synthroid, AbbVie) continues to be the nation's most prescribed drug, and the antipsychotic aripiprazole (Abilify, Otsuka Pharmaceutical) continues to have the highest sales.
The data reflect a rolling 12 months of history (July 2013 - June 2014) on the top 100 drugs by total sales and total prescriptions in the United States.
Following levothyroxine (with 22.6 million prescriptions) as the most prescribed drug in the United States were the cholesterol-lowering drug rosuvastatin (Crestor, AstraZeneca), at about 22.5 million prescriptions; the proton pump inhibitor esomeprazole (Nexium, AstraZeneca), at roughly 18.6 million prescriptions; and the asthma medications albuterol (Ventolin HFA, GlaxoSmithKline), at 17.5 million prescriptions, and fluticasone propionate/salmeterol (Advair Diskus, GlaxoSmithKline), at 15 million prescriptions.
Rounding out the top 10 most prescribed drugs for the period (in order) were the antihypertensive valsartan (Diovan, Novartis), the insulin glargine injection (Lantus Solostar, sanofi-aventis), the antidepressant duloxetine (Cymbalta, Eli Lilly), the attention-deficit drug lisdexamfetamine dimesylate (Vyvanse, Shire), and the antiepileptic pregabalin (Lyrica, Pfizer).
After aripiprazole, which had sales of $7.2 billion for the period of July 2013 through June 2014, the next best selling drugs for the period were the arthritis drug adalimumab (Humira, AbbVie, $6.3 billion), esomeprazole (Nexium, $6.3 billion), rosuvastatin (Crestor, nearly $5.6 billion), and the arthritis drug etanercept (Enbrel, Amgen, nearly $5.1 billion).
Rounding out the top 10 in sales were Advair Diskus ($5.0 billion), the antiviral drug sofosbuvir (Sovaldi, Gilead, $4.4 billion), the arthritis drug infliximab (Remicade, Centocor; $4.3 billion), the insulin glargine injection (Lantus Solostar, sanofi-aventis, $3.8 billion), and the neutropenia drug pegfilgrastim (Neulasta, Amgen; nearly $3.7 billion).
| Table 1. Top 100 Drugs by Monthly Prescription | ||
| Rank | Drug (Brand Name) | Total Prescriptions to June 2014 |
| 1 | Synthroid | 22,664,826 |
| 2 | Crestor | 22,557,735 |
| 3 | Nexium | 18,656,464 |
| 4 | Ventolin HFA | 17,556,646 |
| 5 | Advair Diskus | 15,003,169 |
| 6 | Diovan | 11,401,503 |
| 7 | Lantus Solostar | 10,154,739 |
| 8 | Cymbalta | 10,065,788 |
| 9 | Vyvanse | 10,019,178 |
| 10 | Lyrica | 9,684,884 |
| 11 | Spiriva Handihaler | 9,518,849 |
| 12 | Lantus | 9,358,961 |
| 13 | Celebrex | 8,815,391 |
| 14 | Abilify | 8,777,842 |
| 15 | Januvia | 8,758,309 |
| 16 | Namenda | 7,640,319 |
| 17 | Viagra | 7,584,152 |
| 18 | Cialis | 7,555,933 |
| 19 | Zetia | 7,411,629 |
| 20 | Nasonex | 7,304,210 |
| 21 | Suboxone | 7,011,882 |
| 22 | Symbicort | 6,948,403 |
| 23 | Bystolic | 6,722,578 |
| 24 | Flovent HFA | 5,623,533 |
| 25 | Oxycontin | 5,559,330 |
| 26 | Levemir | 5,554,827 |
| 27 | Xarelto | 5,014,364 |
| 28 | Nuvaring | 5,011,966 |
| 29 | Dexilant | 4,866,178 |
| 30 | Thyroid | 4,834,481 |
| 31 | Benicar | 4,725,628 |
| 32 | Voltaren Gel | 4,709,766 |
| 33 | Proventil HFA | 4,494,004 |
| 34 | Tamiflu | 4,149,835 |
| 35 | Novolog | 4,044,310 |
| 36 | Novolog Flexpen | 4,006,690 |
| 37 | Premarin | 3,984,357 |
| 38 | Vesicare | 3,873,046 |
| 39 | Humalog | 3,858,256 |
| 40 | Benicar HCT | 3,633,026 |
| 41 | Lumigan | 3,283,060 |
| 42 | Afluria | 3,242,605 |
| 43 | Lo Loestrin Fe | 3,154,488 |
| 44 | Janumet | 3,089,749 |
| 45 | Ortho-Tri-Cy Lo 28 | 3,053,738 |
| 46 | Toprol-XL | 3,044,003 |
| 47 | Pristiq | 3,023,546 |
| 48 | Combivent Respimat | 2,994,490 |
| 49 | Vytorin | 2,988,460 |
| 50 | Travatan Z | 2,919,358 |
| 51 | Focalin XR | 2,866,278 |
| 52 | Pataday | 2,757,094 |
| 53 | Humalog Kwikpen | 2,626,530 |
| 54 | Lunesta | 2,590,519 |
| 55 | Avodart | 2,527,583 |
| 56 | Pradaxa | 2,442,678 |
| 57 | Seroquel XR | 2,405,130 |
| 58 | Strattera | 2,387,756 |
| 59 | Minastrin 24 Fe | 2,353,282 |
| 60 | Evista | 2,232,555 |
| 61 | Chantix | 2,151,879 |
| 62 | Zostavax | 2,145,562 |
| 63 | Humira | 1,923,427 |
| 64 | Victoza 3-Pak | 1,902,995 |
| 65 | Exelon | 1,877,942 |
| 66 | Exforge | 1,838,730 |
| 67 | Combigan | 1,821,491 |
| 68 | Dulera | 1,790,677 |
| 69 | Onglyza | 1,784,018 |
| 70 | Welchol | 1,778,218 |
| 71 | Premarin Vaginal | 1,718,405 |
| 72 | Enbrel | 1,627,480 |
| 73 | Xopenex HFA | 1,588,895 |
| 74 | Ranexa | 1,567,961 |
| 75 | Truvada | 1,532,734 |
| 76 | Alphagan P | 1,503,194 |
| 77 | Viibryd | 1,447,730 |
| 78 | Tradjenta | 1,443,791 |
| 79 | Effient | 1,434,572 |
| 80 | Azor | 1,433,045 |
| 81 | Norvir | 1,384,306 |
| 82 | Actonel | 1,339,615 |
| 83 | Namenda XR | 1,319,963 |
| 84 | Amitiza | 1,309,980 |
| 85 | Aggrenox | 1,286,826 |
| 86 | Lotemax | 1,276,480 |
| 87 | Patanol | 1,274,050 |
| 88 | Levitra | 1,273,311 |
| 89 | Advair HFA | 1,272,551 |
| 90 | Uloric | 1,244,536 |
| 91 | Detrol La | 1,225,506 |
| 92 | Asmanex Twisthaler | 1,219,112 |
| 93 | Lipitor | 1,212,376 |
| 94 | Atripla | 1,183,636 |
| 95 | Prempro Low Dose | 1,162,513 |
| 96 | Latuda | 1,123,396 |
| 7 | Novolog Flxpen Mix 70/30 | 1,119,855 |
| 98 | Invokana | 1,106,268 |
| 99 | Epiduo | 1,103,330 |
| 100 | Humulin N | 1,071,673 |
Table 2. Top 100 Drugs by Sales | ||
| Rank | Drug (Brand Name) | Sales Through June 2014 |
| 1 | Abilify | $7,240,043,661 |
| 2 | Humira | $6,310,742,887 |
| 3 | Nexium | $6,303,738,580 |
| 4 | Crestor | $5,672,991,435 |
| 5 | Enbrel | $5,097,263,350 |
| 6 | Advair Diskus | $5,064,138,456 |
| 7 | Sovaldi | $4,469,558,675 |
| 8 | Remicade | $4,342,356,359 |
| 9 | Lantus Solostar | $3,829,943,226 |
| 10 | Neulasta | $3,688,450,342 |
| 11 | Copaxone | $3,677,307,402 |
| 12 | Rituxan | $3,361,247,463 |
| 13 | Spiriva Handihaler | $3,270,501,346 |
| 14 | Januvia | $3,124,826,108 |
| 15 | Lantus | $3,011,654,746 |
| 16 | Atripla | $2,898,264,003 |
| 17 | Cymbalta | $2,839,722,673 |
| 18 | Avastin | $2,784,813,413 |
| 19 | Lyrica | $2,782,036,977 |
| 20 | Oxycontin | $2,524,152,087 |
| 21 | Celebrex | $2,435,800,107 |
| 22 | Epogen | $2,378,212,523 |
| 23 | Truvada | $2,351,681,656 |
| 24 | Diovan | $2,177,824,165 |
| 25 | Levemir | $2,121,663,090 |
| 26 | Gleevec | $2,087,891,457 |
| 27 | Herceptin | $2,032,270,434 |
| 28 | Vyvanse | $1,940,313,035 |
| 29 | Lucentis | $1,932,528,073 |
| 30 | Zetia | $1,930,143,528 |
| 31 | Tecfidera | $1,908,407,807 |
| 32 | Symbicort | $1,901,446,790 |
| 33 | Namenda | $1,774,338,290 |
| 34 | Novolog Flexpen | $1,720,294,797 |
| 35 | Xarelto | $1,546,602,955 |
| 36 | Novolog | $1,466,291,783 |
| 37 | Humalog | $1,418,795,789 |
| 38 | Suboxone | $1,388,999,843 |
| 39 | Tysabri | $1,315,848,323 |
| 40 | Viagra | $1,274,239,087 |
| 41 | Seroquel XR | $1,266,841,322 |
| 42 | Victoza 3-Pak | $1,263,623,179 |
| 43 | Cialis | $1,241,580,547 |
| 44 | Stelara | $1,221,329,301 |
| 45 | Alimta | $1,215,044,019 |
| 46 | Nasonex | $1,190,958,069 |
| 47 | Avonex | $1,146,712,504 |
| 48 | Gilenya | $1,143,648,903 |
| 49 | Humalog Kwikpen | $1,140,418,800 |
| 50 | Flovent HFA | $1,091,998,384 |
| 51 | Prezista | $1,079,469,740 |
| 52 | Janumet | $1,071,110,813 |
| 53 | Renvela | $1,063,062,816 |
| 54 | Isentress | $1,045,929,798 |
| 55 | Procrit | $1,028,448,101 |
| 56 | Orencia | $1,017,584,725 |
| 57 | Dexilant | $1,010,512,519 |
| 58 | Vesicare | $1,001,127,504 |
| 59 | Stribild | $962,264,200 |
| 60 | Olysio | $943,547,154 |
| 61 | Synthroid | $927,886,999 |
| 62 | Neupogen | $922,013,084 |
| 63 | Avonex Pen | $920,097,484 |
| 64 | Reyataz | $918,922,508 |
| 65 | Zytiga | $918,603,420 |
| 66 | Xolair | $902,375,287 |
| 67 | Invega Sustenna | $891,518,099 |
| 68 | Benicar | $884,750,288 |
| 69 | Combivent Respimat | $881,992,234 |
| 70 | Pradaxa | $879,463,846 |
| 71 | Sensipar | $878,283,696 |
| 72 | Xgeva | $844,140,641 |
| 73 | Vytorin | $828,020,808 |
| 74 | Betaseron | $824,758,830 |
| 75 | Aranesp | $824,531,232 |
| 76 | Prevnar 13 | $818,701,788 |
| 77 | Latuda | $803,311,039 |
| 78 | Afinitor | $800,598,342 |
| 79 | Lunesta | $778,412,409 |
| 80 | Ventolin HFA | $771,201,081 |
| 81 | Complera | $756,268,942 |
| 82 | Synagis | $754,510,179 |
| 83 | Bystolic | $736,654,176 |
| 84 | Zyvox | $733,964,492 |
| 85 | Gardasil | $717,881,961 |
| 86 | Sandostatin Lar | $715,506,378 |
| 87 | Benicar HCT | $699,679,537 |
| 88 | Treanda | $692,288,820 |
| 89 | Pristiq | $687,192,710 |
| 90 | Zostavax | $674,280,328 |
| 91 | Erbitux | $669,382,439 |
| 92 | Cimzia | $660,599,949 |
| 93 | Strattera | $658,818,959 |
| 94 | Cubicin | $655,269,663 |
| 95 | Xeloda | $652,443,257 |
| 96 | Tarceva | $638,909,500 |
| 97 | Evista | $638,155,000 |
| 98 | Velcade | $636,704,153 |
| 99 | Sprycel | $635,192,399 |
| 100 | Abraxane | $634,678,206 |
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