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segunda-feira, 12 de junho de 2017

Corticoide para faringite aguda: pouco benefício, não prescrever de rotina


De novo sobre corticoides...
Estudo mostra benefícios modestos e lembremos dos efeitos colaterais

Dexamethasone and acute pharyngitis pain in adults
Studies of oral glucocorticoids for acute pharyngitis pain have generally found only modest benefit but have been limited by confounding factors such as concurrent antibiotic use. In an office-based randomized trial that compared a single dose of dexamethasone with placebo for adults who visited a primary care clinician for acute pharyngitis and were not given an immediate prescription for antibiotics, there was no difference in the proportion of patients who achieved full pain relief at 24 hours, and there was only a small difference in symptom relief at 48 hours (35 versus 27 percent with placebo) [2]. These results support our suggestion to not prescribe glucocorticoids routinely for acute pharyngitis and to limit their use to severely symptomatic patients.
2. Hayward GN, Hay AD, Moore MV, et al. Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial. JAMA 2017; 317:1535.




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